Each row is a drug, each column a cancer subtype. Cells show the strongest known association for that drug in that cancer: approved clinical trial or blank. The repositionable flag means the drug appears as a synthetic-lethal repositioning candidate in cansar; it’s gene-level, not cancer-level.
| Drug | Target | Relationship | GBM | LUAD | SCLC | LUSC | OAC | OSCC | PDAC | Reposition | #cancers |
|---|---|---|---|---|---|---|---|---|---|---|---|
| biospecimen collection, lidocaine, resection | ORM2 | Direct | 1 | ||||||||
| docetaxel, thalidomide | ORM1 | SSL via ORM1 | 4 | ||||||||
| thalidomide | ORM1 | SSL via ORM1 | 2 | ||||||||
| biospecimen collection, lidocaine, resection | ORM1 | SSL via ORM1 | 1 | ||||||||
| ce-mark approved laa closure devices, acetylsalicylic acid, clopidogrel, dabigatran, rivaroxaban, apixaban, edoxaban, phenprocoumon, warfarin | MYC | SSL via MYC | 1 | ||||||||
| celecoxib, cyclophosphamide, etoposide, thalidomide | ORM1 | SSL via ORM1 | 1 | ||||||||
| celecoxib, isotretinoin, temozolomide, thalidomide | ORM1 | SSL via ORM1 | 1 | ||||||||
| celecoxib, temozolomide, thalidomide, adjuvant therapy | ORM1 | SSL via ORM1 | 1 | ||||||||
| chlorpromazine, temozolomide, radiation therapy | ORM1 | SSL via ORM1 | 1 | ||||||||
| dipyridamole, fluorouracil, leucovorin calcium, mitomycin c | ORM1 | SSL via ORM1 | 1 | ||||||||
| irinotecan hydrochloride, thalidomide | ORM1 | SSL via ORM1 | 1 | ||||||||
| nicotinamide, placebo | BST1 | SSL via BST1 | 1 | ||||||||
| peg-interferon alfa-2b, thalidomide | ORM1 | SSL via ORM1 | 1 | ||||||||
| procarbazine hydrochloride, thalidomide | ORM1 | SSL via ORM1 | 1 | ||||||||
| temozolomide, thalidomide | ORM1 | SSL via ORM1 | 1 | ||||||||
| thalidomide, adjuvant therapy | ORM1 | SSL via ORM1 | 1 | ||||||||
| thalidomide, cpt-11, mri scan, quantitative sensory tests (qst) | ORM1 | SSL via ORM1 | 1 |